Faculty Profile

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  • Dr. Achuthan C. Raghavamenon

Dr. Achuthan C. Raghavamenon

Associate Professor BIOCHEMISTRY

  • RESEARCH INTERESTS

    • Oxidised lipids, inflammation, oxidative stress, Metabolic and Degenerative diseases, Atherosclerosis, Cancer

  • POSITIONS HELD

    • Associate Professor, Department of Biochemistry Amala Cancer Research Centre,Amala Nagar, Thrissur, Kerala ( 2014 - Present )
    • Assistant Professor, Departmentof Biochemistry Amala Cancer Research Centre,Amala Nagar, Thrissur, Kerala ( 2011 - 2014 )
    • Teaching Faculty, Graduate School, Southern University, Baton Rouge, LA ( 2010 - 2011 )
    • Adjunct Faculty, Department of Environmental Toxicology, Southern University, Baton Rouge, LA ( 2009 - Present )
    • Sr Postdoctoral Research Associate, Department of EnvironmentalToxicology, Southern University, Baton Rouge, LA ( 2007 - 2011 )
    • Postdoctoral Researcher, Department of Surgery, The Ohio State UniversityMedical Center, Colombus, OH ( 2006 - 2007 )
    • Postdoctoral Fellow, Department of Pathology, LSU Health Sciences Center, New Orleans, LA ( 2005 - 2006 )
    • Research Associate, Department of Plant Biotechnology and Molecular Biology, Kerala Agricultural University, Kerala ( 1998 - 2005 )

  • AWARDS

    • H.S. Mehta Memorial Award for Best Research paper (Oral ) presented at National seminar on” New oersoective in Spices, Medicinal and Aromatic Plants, Calicut,.27-29-2003

  • PROJECTS

    • Nonalcoholic and alcoholic liver diseases promote stress resistant mitochondria mediated hepatic cellular proliferation: Implication in hepatocellular carcinoma development
      Funding Agency: ICMR ( 2019 - 2022 )
    • Effect of Desmodium gyrans DC.on reverse cholesterol transport: implication in atheroprotection.
      Funding Agency: DST New Delhi ( 2013 - 2016 )
    • Effect of Baliospermum montanum in inflammation and oxidative injury.
      Funding Agency: KSCSTE ( 2014 - 2017 )
    • Identification of dicarboxylic acidsfromoxidation of peroxidisedomega 3 fattyacids and study on itsbiologicalefficacy.
      Funding Agency: ICMR ( 2012 - 2015 )
    • Hepatoprotective effect of lutemax 2020
      Funding Agency: Omni Active

  • PUBLICATIONS

    • SP kanidiyil, A Jose, C Mohanan, SP Illam, AC Raghavamenon (2024) Virgin coconut oil mitigates ageing-associated oxidative stress and dyslipidaemia in male Wistar rats. Nutrition Metabolism and Cardiovascular disease. doi.org/10.1016/j.numecd.2024.08.012
    • V.Gopinath,A Maria Davis, TK Menon, AC Raghavamenon(2024)Alcohol promotes Liver Fibrosis in High Fat Induced Diabetic Rats. Journal of basic and clinical physiology and pharmacology. doi.org/10.1515/jbcpp-2024-0042
    • S Prabha, S Tamoli, AC Raghavamenon, KA Manu (2024)Virgin Coconut Oil Alleviates Dextran Sulphate–Induced Inflammatory Bowel Disease and Modulates Inflammation and Immune Response in Mice. Journal of the American Nutrition Association 43 (3), 261-271
    • CM Pareeth, KPS Hussan, D Anu, N Meera, D Mathew, R Valsalan AC Raghavamenon & TD Babu (2024) Antiproliferative effect of Saraca asoca methanol bark extract on triple negative breast cancer (TNBC) Future Journal of Pharmaceutical Sciences 10 (1), 52
    • KPS Hussan, A Davis, S Lekshmi, MS Thayyil, AC Raghavamenon, &TD Babu (2024)Evaluation of the binding efficacy of flavonol derivatives on estrogen receptors (ER) with respect to ring B hydroxylation. Results in Chemistry 7, 101544
    • LJ Aloor, S Skariyachan, AC Raghavamenon, KM Kumar, R Narayanappa, A Utharkkar ,  V Niranjan&T Cheriyan (2023)BRCA1/TP53 tumor proteins inhibited by novel analogues of curcumin—Insight from computational modelling, dynamic simulation and experimental validation. International Journal of Biological Macromolecules 253, 126989
    • D Girija, K Deepa, T Chubicka, PR Shidhi, S Hussan, AC Raghavamenon .& TD Babu (2023),Structural and functional validation of a cloned parasporin from Bacillus thuringiensis isolate KAU 41 native to Western Ghats of India. Proteins: Structure, Function, and Bioinformatics 91 (11), 1487-1495
    • SP Kandiyil, SP Illam, AC Raghavamenon (2023)Normolipidic diet containing deep-fried saturated and unsaturated fatty acids rich edible oils promotes metabolic dysregulation and inflammatory microenvironment in Wistar rats. Food and Chemical Toxicology 180, 114029
    • CM Pareeth, N Meera, P Silpa, KM Thara, AC Raghavamenon, TD Babu(2023)Analysis of anticancer potential of Kingiodendron pinnatum (DC.) Harms. Clinical Phytoscience 9 (1), 4
    • L Laynes, AC Raghavamenon, DS Atkins-Ball, RM Uppu (2022) NADPH Oxidase System Mediates Cholesterol Secoaldehyde-Induced Oxidative Stress and Cytotoxicity in H9c2 Cardiomyocytes. Cardiovascular Signaling in Health and Disease, 213-234
    • M Suseela, J Padikkala, TD Babu, RM Uppu, AC Raghavamenon (2022)Atherosclerotic Plaque Regression: Future Perspective. Cardiovascular Signaling in Health and Disease, 367-378
    • V Gopinath, MKA Shamsitha, V Penarveettil Nair, P Seena, RM Uppu AC Raghavamenon(2022)Thermally oxidized coconut oil as fat source in high-fat diet induces hepatic fibrosis in diabetic rat model. Cell Biochemistry and Biophysics 79 (3), 629-639
    • A Narayanankutty, BT Kuzhivelil, AC Raghavamenon (2020). A High-Fructose Diet Formulated with Thermally Oxidized Monounsaturated Fat Aggravates Metabolic Dysregulation in Colon Epithelial Tissues of Rats Journal of the American College of Nutrition, 1-12. 
    • A Narayanankutty, SP Illam, V Rao, S Shehabudheen,AC Raghavamenon (2020 Hot-processed virgin coconut oil abrogates cisplatin-induced nephrotoxicity by restoring redox balance in rats compared to fermentation-processed virgin coconut oil. Drug and Chemical Toxicology, 1-10.
    • A Jose, K Elango, SRV Madhunapantula, AC Raghavamenon (2020)Tricaproin isolated from Simarouba glauca inhibit colorectal cancer cell growth: A mechanistic approach in vitro and in vivo. Materials Today: Proceedings.2011-2
    • Raghavamenon A.C., Gao X., Atkins-Ball D.S., Varikuti S., Parinandi N.L., Uppu R.M. (2020) ‘Ozone-Specific’ Oxysterols and Neuronal Cell Signaling. In: Berliner L., Parinandi N. (eds) Measuring Oxidants and Oxidative Stress in Biological Systems. Biological Magnetic Resonance, vol 34. Springer, Cham. https://doi.org/10.1007/978-3-030-47318-1_7
    • Narayanankutty A, Nair A,  Illam SP, A. Upaganlawar and  Raghavamenon AC (2020). Curcumin Enriched VCO Protects against 7,12-Dimethyl Benz[a] Anthracene-Induced Skin Papilloma in Mice. Nutrition and Cancer (10.1080/01635581.2020.1778745).
    • Illam SP, Hussain A, Elizabeth A, Narayanankutty A, Raghavamenon AC ( 2019) Natural combination of phenolic glycosides from fruits resists pro-oxidant insults to colon cells and enhances intrinsic antioxidant status in mice. Toxicology Reports  (18:6, 703-711)
    • Sheela DL, Narayanankutty A, Nazeem PA, Raghavamenon AC, Muthangaparambil SR (2019). Lauric acid induce cell death in colon cancer cells mediated by the epidermal growth factor receptor downregulation: An in silico and in vitro study. Human and  Experimental Toxicology  38(7):753-761
    • Cyril N, George JB, Joseph L, Raghavamenon AC and V P Sylas (2019). Assessment of antioxidant, antibacterial and anti-proliferative (lung cancer cell line A549) activities of green synthesized silver nanoparticles from Derris trifoliate. Toxicology Research (8; 2 297–308)
    • Narayanankutty A, Anil A, Illam SP, Kandiyil S P, .Raghavamenon AC (2018) Non-polar lipid carbonyls of thermally oxidized coconut oil induce hepatotoxicity mediated by redox imbalance. Prostaglandins Leukotrienes  and Essential  Fatty Acids. 138:45-51
    • Narayanankutty A,Illam S,& AC Raghavamenon (2018) Health impacts of different edible oils prepared from coconut ( Cocos nucifera ): Acomprehensive reviewTrends in Food Science & Technology DOI: 10.1016/j.tifs.2018.07.025
    • Narayanankutty A., Gopinath M, Muneera V, smitha KR,  Babu TD and A. C Raghavamenon (2018) Nonenzymatic convertion of primary oxidation products of Docosahexaenoic acid into less toxic molecules. Spectrochemica Acta Part A Molecular and Biomolecular Spectroscopy
    • T Chubicka, D Girija, K Deepa, S Salini, N Meera, AC Raghavamenon& TD Babu (2018) A sparasporine from Bacillus thuringiensis native to Penisular India induces apoptosis ain cancer through intrinsic pathway. Journal of biosciences 43 (2), 407- 416
    • Indu M.S., Jose Padikkala, AC.Raghavamenon. Partially purified aqueous fraction of Desmodium gyrans DC improves reverse cholesterol transport and lipoprotein metabolism. Journal of Environmental Pathology, Toxicology and Oncology (Accepted) (2017)
    • Indu M.S., Jose Padikkala, A C.Raghavamenon. Safety assessment of partially purified HDL enhancing phyto components from Desmodium gyrans DC. International Journal of Advanced Research (IJAR)  (2018)
    • Narayanankutty A., Palliyil D.M., Kuruvilla K. and A. C Raghavamenon (2017) Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats. Journal of the Science of Food and Agriculture, (DOI. 10.1002/jsfa.8650).
    • Roy N., Nazeem P. A., Babu T. D., Abida P. S., Narayanankutty, A., Valsalan R., Valsala P. A., and Raghavamenon A. C. (2017). EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide. Interdisciplinary Sciences: Computational Life Sciences (DOI 10.1007/s12539-017-0227-6).
    • Lekshmi Sheela, D., Abdulla Nazeem P, Narayanankutty A, Shylaja Muthangaparambil R, Davis S P, James P, Valsalan R, Devassy Babu T and Raghavamenon A C (2017). Coconut phytocompounds inhibits polyol pathway enzymes: Implication in prevention of microvascular diabetic complications. Prostaglandins, Leukotrienes and Essential Fatty Acids;127: 20-24.
    • S.P. Illam, A. Narayanankutty, E.M. Shaji, V. Remya, M. Rosemol & A.C. Raghavamenon (2017) Epithelial Mesenchymal Transition in Cancer Progression: Preventive Phytochemicals. Recent Patents on Anti-Cancer Drug Discovery12 (3): 234-246.
    • S.P. Illam, A. Narayanankutty, & A.C. Raghavamenon (2017) Polyphenols of Virgin coconut oil prevent pro-oxidant mediated cell death. Toxicology Mechanism and Methods27(6):442-450.
    • A. Narayanankutty, A. Kottekkat, E.M.  Shaji, P.I. Soorya, M.S. Indu., &A.C. Raghavamenon (2016) Vitamin E supplementation modulates the biological effects of Omega 3 fatty acids in naturally aged rats. Toxicology Mechanism and Methods27(3): 207-214DOI 10.1080/15376516.2016.1273431.
    • Lekshmi D.S., Nazeem P.A.,A. Narayanankutty, Jeksy J.M., &A.C. Raghavamenon (2016) In Silico and Wet Lab Studies Reveal the Cholesterol Lowering Efficacy of Lauric Acid a Medium Chain Fat of Coconut Oil. Plant foods for Human Nutrition 71 (4): 410-415DOI 10.1007/s11130-016-0577-y
    • A. Narayanankutty, J.M Jeksy., MS. Indu., K.R. Smitha, EM.  Shaji, P.I. Soorya, TD. Babu, TK. Balu & A.C. Raghavamenon (2016) Deep fried edible oils disturbs hepatic redox equilibrium and heightens lipotoxicity and hepatosteatosis in rats. Human and Experimental ToxicologyDOI 10.1177/0960327116674530.
    • A. Narayanankutty, V. Muneera, J.M Jeksy., K.R. Smitha., M S. Indu, TD. Babu&AC. Raghavamenon (2016) Omega 3 fatty acids: Do they raise health concern? JSM Biochemistry and Molecular biology 3(1): 1016.
    • N. Roy, S. Davis, A. Narayanankutty, P A. Nazeem, TD Babu., PS. Abida, P A. Valsala &AC. Raghavamenon (2016). Garlic phytocompounds possess anticancer activity by specifically targeting breast cancer biomarkers: An In silico study. Asian Pacific Journal of Cancer Prevention 17(6):2883-2888.
    • Divya M K, Salini S, Meera N, Lincy L, Seema M, A. C. Raghavamenonand Babu T D (2016). Attenuation of DMBA/croton oil induced mouse skin papilloma by Apodytesdimidiata mediated by its antioxidant and antimutagenic potential. Pharm Biol 15, 1-11.
    • Arunaksharan N, Reshma K. M., Shabna K. A., Smitha K. R., Indu M. S., Jeksy J. M., Balu T. K. and A. C. Raghavamenon (2016). Virgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats. Journal of food science and technology,53 (1): 895-901. 
    • Divya M K, Lincy L, A. C. Raghavamenon and Babu T D (2016). Ameliorative effect of Apodytesdimidiata on cisplatin-induced nephrotoxicity in Wistar rats. Pharm Biol3, 1-9. 
    • Salini S, Divya M K, Chubicka T, Meera N, Fulzele D P, A. C.Ragavamenonand Babu T D (2016). Protective effect of Scutellaria species on AAPH-induced oxidative damage in human erythrocyte. Journal of basic and clinical physiology and pharmacology 27(4), doi.org/10.1515/jbcpp-2015-0081
    • Jeksy Jos Manalil, Indu M. S., Smitha K. R., Arunaksharan N and A. C. Raghavamenon (2015). Component Authentication and Standardisation of an Anti-atherosclerotic Herbal Formulation-GSTC3. Pharmacognosy Journal, 7 (6): 339-343.
    • Divya M K, Salini S, Chubicka T, Raghavamenon A C and Babu T D (2015). Evaluation of Cytotoxic and Antitumour Properties of Apodytesdimidiata and Characterisation of the Bioactive Component. Planta Med 81, 1705-1711.
    • Manalil J J, Baby M, Ramavarma S K, Suseela I M, Padikkala J and A.C. Raghavamenon (2015). Development of an Anti-Atherosclerotic Polyherbal Formulation: GSTC3. J Environ PatholToxicolOncol 34, 237-248.
    • P.S. Vipin, N.M. Johannah , M.Seema ,L. Lincy , A. C. Raghavamenon and J. Padikkala (2015) Enhancement of functional HDL contributing to anti-atheorogenic efficacy of Desmodium gyrans DC. WJPPS,4: 1631-1646
    • S.S Nair, J.J Manalil, S.K Ramavarma, I.M Susheela, A. Thekkepatt and A.C Raghavamenon (2015) Virgin coconut oil supplementation ameliorates cyclophosphamideinduced systemic toxicity in mice. Human experimental toxicology, 35: 205-212.

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