Focus of lab

• Biomedical approach to validate traditional and plant-based interventions, bridging Ayurvedic knowledge with modern biochemical and pharmacological  aspects
• Uncovering mechanisms by which dietary oils and herbal extracts modulate oxidative stress, cholesterol metabolism, inflammation, and tumor  development and metastasis
• Develop dietary model for   advanced fatty liver disease and hepatocellular carcinoma (HCC) and understand the role of mitochondrial adaptation in neoplastic development
• Study the progressive changes associated with chemoresistance and metastatic acquisition by non-metastatic cancer cells and discover the potential of natural products in chemo-sensitization.
• Developing a safe herbal formulation for the effective management of Atherosclerosis

Achievements

• Developed and in-house Anti-atherosclerotic polyherbal formulation and established its complementing action with Atorvastatin 
• Reverse cholesterol pathway enhancing  efficacy of Desmodium gyrans documented
• Identified differetnt herbal components with anti- cancer activity
• Demonstrated  virgin coconut oil’s (VCO) ability to reduce hepatic steatosis, restore redox balance, and provide hepatoprotection in animal models
• Investigations revealed that thermally oxidized cooking oils  dysregulate carbohydrate and lipid metabolism  and disrupt hepatic redox homeostasis and accelerate lipid-related liver damage in rats,
• A short term dietary model for advanced NASH was developed and using this model exacerbated fatty liver disease progression in diabetic rats under chronic alcoholism has been documented.
• PGC 1 alfa/P53 axis mediated mitochondrial adaptation has been identified as the mechanistic basis for exacerbated NASH especially in female rats.