Dr. Manu K Aryan

PUBLICATIONS

• Chai, T.F.#, Manu, K.A.#(Equal First author), Casey, P.J. et al. Isoprenylcysteinecarboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal. Oncogene (2020). https://doi.org/10.1038/s41388-020-1364-7
• Manu KA, Cao PHA, Chai TF, Casey PJ, Wang M.p21cip1/waf1 Coordinate Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress.Cancers (Basel). 2019 Aug 3;11(8). pii: E1112. doi: 10.3390/cancers11081112. (Review).
• Manu KA, Chai TF, Teh JT, Zhu WL, Casey PJ, Wang M. Inhibition of IsoprenylcysteineCarboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. Molecular Cancer Therapeutics . 2017 May;16(5):914-923. doi: 10.1158/1535-7163.MCT-16-0703. Epub 2017 Feb 6. PubMed PMID: 28167504.
• Shanmugam MK, Ahn KS, Lee JH, Kannaiyan R, Mustafa N, Manu KA, Siveen KS, Sethi G, Chng WJ, Kumar AP. Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma.Front Pharmacol. 2018 May 3;9:365. doi: 10.3389/fphar.2018.00365. eCollection 2018.
  
• Manu KA, Shanmugam MK, Ramachandran L, Li F, Siveen KS, Chinnathambi A, Zayed ME, Alharbi SA, Arfuso F, Kumar AP, Ahn KS, SethiG.Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κBsignalling cascade in gastric cancer.Cancer Lett. 2015 Jul 10;363(1):28-36. doi: 10.1016/j.canlet.2015.03.033. Epub 2015 Mar 28 (Corrigendum Cancer Lett. 2018 Apr 28;420:259. doi: 10.1016/j.canlet.2018.01.003. Epub 2018 Jan 17.)
• Kanjoormana A. Manu, Muthu K. Shanmugam, Feng Li1, Luxi Chen, KodappullySivaramanSiveen, Kwang Seok Ahn, Alan Prem Kumar Gautam Sethi.. Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B regulated gene products, Journal of Molecular Medicine(Berl). 2014 Mar;92(3):267-76.
• Manu KA, Shanmugam MK, Ong TH, Subramaniam A, Siveen KS, Perumal E, Samy RP, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G.Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma.PLoS One. 2013;8(3):e57015. doi: 10.1371/journal.pone.0057015. Epub 2013 Mar 5.
• Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT, Ashktorab H, Tan P, Ahn KS, Yap CW, Kumar AP, Sethi G. Isorhamnetin inhibits proliferation, invasion, and induces apoptosis through the modulation of peroxisome proliferator-activated receptor-gamma activation pathway in gastric cancer. Journal of Biological Chemistry,2013, 287 (45), 38028-38040
  
• Subramaniam A, Loo SY, Rajendran P, Manu KA, Perumal E, Li F, Shanmugam MK, Siveen KS, Park JI, Ahn KS, Hui KM, Kumar AP, SethiG.An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins.2013. Apoptosis 18 (10), 1175-1187
• Kanjoormana Aryan Manu, Muthu K. Shanmugam, Lalitha Ramachandran, Feng Li, Chee Wai Fong, Alan Prem Kumar, Patrick Tan, Gautam Sethi. First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. Clinical Cancer Research 2012 Apr 15;18(8):2220-9. Epub 2012 Feb 20.
• Kanjoormana Aryan Manu1, Hui Sin Hay, Peramaiyan Rajendran, Muthu K Shanmugam, Feng Li, RadhamaniKannaiyan, Shireen Vali, Shweta Kapoor, Bhargavi Ramesh, Pradeep Bist, Evelyn S C Koay, Lina H.K Lim, Kwang Seok Ahn,Alan Prem Kumar, and Gautam SethiPlumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4. Mol Cancer. 2011 Sep 1;10:107.
• RadhamaniKannaiyan#, Kanjoormana Aryan Manu # (Equal First author),LuxiChen , Feng Li1, Peramaiyan Rajendran, Arul Joe Win1, Alan Prem Kumar, Gautam Sethi, Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-Terminal Kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. Apoptosis2011 Oct;16(10):1028-41.
• Muthu K Shanmugam#, Kanjoormana Aryan Manu # (Equal First author), Lalitha Ramachandran, Tina H.Ong2,Rohit Surana, Pradeep Bist4, Lina H.K Lim, Alan Prem Kumar, Kam M.Hui and Gautam SethiInhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. International Journal of Cancer 2011 Oct 1;129(7):1552-63. doi: 10.1002/ijc.26120. Epub 2011 Jul 20
  
• MaralinganadoddiPanchegowdaSadashiva, Basappa, SivananjuNajundaswamy, Feng Li, Kanjoormana Aryan Manu et al, Anticancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives. BMC Chemical Biology 2012, 12:5.
• Rajendran P, Li F, Aryan MK, Shanmugam MK, Loo SY, Kumar AP, Sethi G. γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an anti-proliferative, pro-apoptotic and chemosensitizing agent. British journal of pharmacology 2010 Dec. ;163(2):283-98
• Kuttan G, Pratheeshkumar P, Manu K.A,. Inhibition of tumor progression by naturally occurring terpenoids. Pharmaceutical Biology2011 Oct;49(10):995-1007.( Review )
• Kanjoormana Manu, GirijaKuttan. Antiangiogenic activity of Ursolic acid. Integrative cancer therapies 2010 Jun; 9(2)
• K.A Manu, GirijaKuttan. Punarnavine induces apoptosis in B16F-10 melanoma cells by inhibiting NF-kB Signaling. Asian Pacific Journal of Cancer Prevention.2009;10(6):1031-7.
• K.A. Manu,GirijaKuttan. Immunomodulatory activities of Punarnavine, an alkaloid from Boerhaaviadiffusa. Immunopharmacology and Immunotoxicology 2009;31(3):377-87.
• K.A. Manu,GirijaKuttan. Anti-metastatic potential of Punarnavine, an alkaloid from Boerhaaviadiffusa.Linn. Immunobiology (2009) 214(4):245-55.
• K.A. Manu,GirijaKuttan. Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-κB mediated activation of bcl-2 in B16F-10melanoma cells. International Immunopharmacology (2008) 8, 974–981.
• K.A. Manu,GirijaKuttan. Boerhaaviadiffusastimulates cell-mediated immune response by upregulating IL-2 and downregulating the pro-inflammatory cytokines and GM-CSF in b16f-10 metastatic melanoma bearing miceJournal of experimental therapeutics and oncology, (2008), 7; 17-29.
• K. A. Manu and GirijaKuttan, 'Effect of Punarnavine, an Alkaloid from Boerhaaviadiffusa, on Cell-Mediated Immune Responses and TIMP-1 in B16F-10 Metastatic Melanoma-Bearing Mice', Immunopharmacology and Immunotoxicology, (2007) 29:3, 569 – 586.
• K.A. Manu, P.V. Leyon and GirijaKuttanStudies on the Protective Effects of Boerhaaviadiffusa L. Against Gamma Radiation Induced Damage in Mice, Integr Cancer Ther2007; 6; 381

Editorial (Guest Editor)

• PoyilPratheeshkumar, Young-Ok Son, Preethi Korangath, Kanjoormana Aryan Manu, and KodappullySivaramanSiveen. Phytochemicals in Cancer Prevention and Therapy. Volume 2015, Article ID 324021, 2 pages

SEMINARS/ Seminar proceedings

• Invited talk, International seminar on Lifestyle Diseases, Feb 18, 2020 National College, Manacaud, Thiruvanandapuram, Kerala, India
• Manu KA, Chai TF, Teh JT, Zhu WL, Casey PJ, Wang M. Targeting post prenylation processing enzymes in Pancreatic cancer, Annual conference, Indian Association for Cancer research Feb 5-7, Thiruvanandapuram, Kerala, India
• Manu KA, Chai TF, Teh JT, Zhu WL, Casey PJ, Wang M. Targeting ICMT in Pancreatic cancer. American Association of for Cancer Research (AACR) Annual meeting 2018, McCormick Place, Chicago, IL, USA. From 14th April 2018 to 18th April 2018
• Invited talk, Rev Father Isaac Alappat Endowment Seminar. Christ College, Irinjalakuda, Thrissur, Kerala, India 13th December 2018.
• Invited talk, St. Thomas’ College, Thrissur, Kerala, India. Research Dept. of Botany, Golden Jubilee lecture Series. December 2017.
• Invited talk on “Gamma-tocotrienol potentiates the antitumor activity of capecitabine in vitro and in xenograft mouse model of human gastric cancer”.Second International Conference on Holistic Medicine (ICHM-2011) Kottayam, Kerala, India, Sept 2011.
• Invited talk on “ Simvastasin Sensitizes Gastric cancer towards Capecitabine”. International Seminar o Biotechnology. Karunya University, Coimbatore. TN, India. December 2011.
• Manu KA, Chai TF, Teh JT, Zhu WL, Casey PJ, Wang M. Inhibition of ICMT Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. DUNES Symposium, DUKE-NUS Medical School, Singapore, 30th October 2017.
  
• R Kannaiyan, MK Aryan, MK Shanmugam, F Li, G SethiCelastrol Overcomes Chemoresistance in Vitro and Potentiates the Effect of Bortezomib Against Human Multiple Myeloma in Nude Mice Mode Blood 120 (21), 5017-5017
• Lalitha Ramachandran1, Manu Kanjoormana Aryan1, Chen Luxi2, Li Feng1, Peramaiyan Rajendran1, Chun Wei Yap1, Alan Prem Kumar2, and Gautam Sethi1 Abstract 1978: Isorhamnetin modulates PPAR activation pathway leading to the suppression of proliferation, invasion and induction of apoptosis in gastric cancer.Proceedings: AACR 103rd Annual Meeting 2012-- Mar 31-Apr 4, 2012; Chicago, IL. Cancer Research: April 15, 2012; Volume 72, Issue8, Supplement1 doi: 10.1158/1538-7445.AM2012-1978.
• Nanjunda Swamy S, Raghu Ningegowda, Rajendran P, Basappa, Feng Li1, Ranjith. S, Manu KA, Shanmugam MK, Rangappa KS, Priya BS, Lim LH , Alan Prem Kumar and Gautam Sethi. Identification of a novel 4, 6-disubstituted-1, 2, 4-triazolo-1, 3, 4-thiadiazole derivative that can inhibit proliferation, and induce apoptosis by modulating NF-κB activation in tumor cells. Poster presentation. Mitochondria, Apoptosis and Cancer Conference, National University of Singapore. Singapore. 27th -29th October, 2011.
• Manu Aryan, Muthu K Shanmugham, Lalitha Ramachandran and Gautam Sethi. “ Potential role of gamma-tocotrienol as a chemosensitizer in xenograft mouse model of human gastric cancer” BIT's 4th World Cancer Congress, May 22-25, 2011 Dalian, China
• Manu Aryan, Muthu K Shanmugham, Lalitha Ramachandran and Gautam Sethi. Poster “Gamma-Tocotrienol, A Multitargeted Agent, Can Enhance Antitumor Activity Of Capecitabine In Vitro And In Xenograft Mouse Model Of Human Cancer. 9th International Gastric Cancer Congress (IGCC 2011)20 to 23 April 2011. Seoul, Korea (South).
• Oral presentation on “Gamma-tocotrienol potentiates the antitumor activity of capecitabine in vitro and in xenograft mouse model of human gastric cancer”. Manu Aryan, Muthu K Shanmugham, Lalitha Ramachandran and Gautam Sethi IACR Satellite meeting “Inhibition of Tumor progression” Amala Cancer Research Centre, Thrissur, Kerala, India, Feb 2011.
• Manu KA, GirijaKuttan. Poster on “Glycyrrhizic acid induces apoptosis in B16F-10 melanoma cells by inhibiting NF- κB induced Bcl-2 activation and activating the pro-apoptotic signaling pathways mediated by p53 and caspase-3”in the 2nd International Symposium on Translational Research, Lonavala, Mumbai. India. December 2007.
• Manu KA, GirijaKuttan. Poster on “Anti-angiogenic activity of Ursolic acid” in the International Symposium on Novel Strategies for Targeted Prevention and Treatment of Cancer. School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. December, 2008.