Lipid metabolism, Cancer, Reproductive Biology, Ion channels
POSITIONS HELD
Associate Professor, Dept. of Biochemistry, Amala Cancer Research Centre, Thrissur, Kerala, INDIA.
( 2017 - Present )
Research Specialist, Dept of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA.
( 2015 - 2016 )
Postdoctoral Research Fellow, Dept of Pharmacology, University of Iowa, IA, USA.
( Aug 2014 - Dec 2014 )
Postdoctoral Research Fellow Ottawa Hospital Research Institute, Ottawa, Canada.
( 2010 - 2013 )
Postdoctoral Research Fellow Kent State University, Kent, OH, USA.
( 2007 - 2010 )
Project Assistant Level-IV Centre for Cellular and Molecular Biology, Hyderabad, INDIA.
( 2006 - 2007 )
Project Associate National Institute of Immunology, New Delhi, INDIA.
( 2002 - 2006 )
PROJECTS
Studies on lipid metabolism in Sertoli cells with special focus on sulphated glycolipid metabolism. Funding agency: Indian Council of Medical Research.
Funding Agency: ICMR
PUBLICATIONS
Chankaramkandath Vasu A, Tharakan S, Kadunganattil S. Comparative antioxidant analysis of extracts prepared from Indigofera longiracemosa aerial parts identifies leaf methanolic extract as a promising antioxidant. Nat Prod Res. 2024 Mar 22:1-5. doi: 10.1080/14786419.2024.2331023. Epub ahead of print. PMID: 38516708.
Saewu A, Kongmanas K, Raghupathy R, Netherton J, Kadunganattil S, Linton JJ, Chaisuriyong W, Faull KF, Baker MA, Tanphaichitr N. Primary Sertoli Cell Cultures from Adult Mice Have Different Properties Compared with Those Derived from 20-Day-Old Animals. Endocrinology. 2020 Jan 1;161(1): bqz020. doi: 10.1210/endocr/bqz020. PMID: 31730175; PMCID: PMC7188083
Saewu A, Kadunganattil S, Raghupathy R, Kongmanas K, Diaz-Astudillo P, Hermo L, Tanphaichitr N. Clusterin in the mouse epididymis: possible roles in sperm maturation and capacitation. Reproduction. 2017 Dec;154(6):867-880. doi: 10.1530/REP-17-0518. Epub 2017 Oct 2. PMID: 28971894.
Gupte RP, Kadunganattil S, Shepherd AJ, Merrill R, Planer W, Bruchas MR, Strack S, Mohapatra DP. Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide. Neuropharmacology. 2016 Feb; 101:291-308. doi: 10.1016/j.neuropharm.2015.10.006. Epub 2015 Oct 9. PMID: 26456351; PMCID: PMC4681664.
Dudiki T, Kadunganattil S, Ferrara JK, Kline DW, Vijayaraghavan S. Changes in Carboxy Methylation and Tyrosine Phosphorylation of Protein Phosphatase PP2A Are Associated with Epididymal Sperm Maturation and Motility. PLoS One. 2015 Nov 16;10(11): e0141961. doi: 10.1371/journal.pone.0141961. PMID: 26569399; PMCID: PMC4646675.
Xu H, Kongmanas K, Kadunganattil S, Smith CE, Rupar T, Goto-Inoue N, Hermo L, Faull KF, Tanphaichitr N. Arylsulfatase A deficiency causes seminolipid accumulation and a lysosomal storage disorder in Sertoli cells. J Lipid Res. 2011 Dec;52(12):2187-2197. doi: 10.1194/jlr.M019661. Epub 2011 Oct 2. PMID: 21965315; PMCID: PMC3220287.
Soler DC, Kadunganattil S, Ramdas S, Myers K, Roca J, Slaughter T, Pilder SH, Vijayaraghavan S. Expression of transgenic PPP1CC2 in the testis of Ppp1cc-null mice rescues spermatid viability and spermiation but does not restore normal sperm tail ultrastructure, sperm motility, or fertility. Biol Reprod. 2009 Aug;81(2):343-52. doi: 10.1095/biolreprod.109.076398. Epub 2009 May 6. PMID: 19420386; PMCID: PMC2849817.
Chakravarty S, Kadunganattil S, Bansal P, Sharma RK, Gupta SK. Relevance of glycosylation of human zona pellucida glycoproteins for their binding to capacitated human spermatozoa and subsequent induction of acrosomal exocytosis. Mol Reprod Dev. 2008 Jan;75(1):75-88. doi: 10.1002/mrd.20726. PMID: 17486637.
Chakravarty S, Suraj K, Gupta SK. Baculovirus-expressed recombinant human zona pellucida glycoprotein-B induces acrosomal exocytosis in capacitated spermatozoa in addition to zona pellucida glycoprotein-C. Mol Hum Reprod. 2005 May;11(5):365-72. doi: 10.1093/molehr/gah165. Epub 2005 Apr 1. PMID: 15805145.
Somanath PR, Suraj K, Gandhi KK. Caprine sperm acrosome reaction: promotion by progesterone and homologous zona pellucida. Small Rumin Res. 2000 Aug 1;37(3):279-286. doi: 10.1016/s0921-4488(99)00148-0. PMID: 10867326.
