Dr. Manu K Aryan

Assistant Professor IMMUNOLOGY

• RESEARCH INTERESTS

  • Cancer drug discovery, cancer biology, cancer stem cell biology, Chemo resistance, apoptosis, autophagy, angiogenesis, metastasis, tumor immunology, RAS regulated signaling, targeting post translational lipid modification in cancer cells.

• POSITIONS HELD

  • Assistant Professor and PI, Tumor Immune Micro-Environment Laboratory (TIME Lab), Dept. of Immunology, Amala Cancer Research Centre, Thrissur, Kerala, India ( 2020 - Present )
  • Associate editor, Frontiers in Oncology, Gastrointestinal cancers section, Lausanne, Switzerland ( 2020 - Present )
  • Academic editor, Journal of Oncology, Wiley, USA ( 2020 - 2024 )
  • Post-Doctoral Research Fellow, Cancer and Stem Cell Biology, DUKE- National University of Singapore Medical School, Singapore. ( 2012 - 2020 )
  • Post-Doctoral Research Assistant, Dept. of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore ( 2010 - 2012 )

• AWARDS

  • SERB-SRG Start Up Research Grant. Science and Engineering Research Board, Dept. of Science and Technology (DST), Govt. of India 2021.
  • Fr. Gabriel Golden Jubilee memorial prize 2008 for best publication from Amala Cancer Research Centre, Kerala, India

• PROFESSIONAL MEMBERSHIPS

  • European Association for cancer Research (EACR)
  • American Association for Cancer Research (AACR)(Associate member)
  • Indian Association for Cancer Research (IACR)(Life member)
  • Nutritional Society of India
  • European Federation of Biotechnology

• PUBLICATIONS

  • Manu, Kanjoormana Aryan, M. D. Bronte, and Emilio Francesco Giunta.(ebook) "Reviews in Gastrointestinal Cancers." Frontiers in Oncology 13: 1252665
  • Prabha, Silpa, Sanjay Tamoli, Achuthan C. Raghavamenon, and Kanjoormana Aryan Manu. "Virgin Coconut Oil Alleviates Dextran Sulphate–Induced Inflammatory Bowel Disease and Modulates Inflammation and Immune Response in Mice." Journal of the American Nutrition Association (2023): 1-11.
  • Devan, Aswathy R., Bhagyalakshmi Nair, Manu Kanjoormana Aryan, Vijayastelar B. Liju, Joel Joy Koshy, Bijo Mathew, Arun Valsan, Hoon Kim, and Lekshmi R. Nath. "Decoding Immune Signature to Detect the Risk for Early-Stage HCC Recurrence." Cancers 15, no. 10 (2023): 2729.
  • Manu, Kanjoormana Aryan, M. D. Bronte, and Emilio Francesco Giunta. "Reviews in Gastrointestinal Cancers." Frontiers in Oncology 13: 1252665.
  • Jose A, Bavetta MG, Martinelli E, Bronte F, Giunta EF, Manu KA. Hepatocellular Carcinoma: Current Therapeutic Algorithm for Localized and Advanced Disease. J Oncol. 2022 Dec 31;2022:3817724. doi: 10.1155/2022/3817724. PMID: 36624801; PMCID: PMC9825221. (Review) (Impact Factor: 4.501)
  • Kumar DP, Manu KA, Macha MA. Editorial: The role of non-coding RNAs in gastrointestinal cancer. Front Oncol. 2022 Nov 8;12:1056897. doi: 10.3389/fonc.2022.1056897. PMID: 36425552; PMCID: PMC9679618. (Editorial) (Impact Factor: 6.244)
  • Manu KA, Harikumar KB, Ishimoto T. Editorial: Targeting Pancreatic Cancer: Strategies and Hopes. Front Oncol. 2022 Mar 31;12:873682. doi: 10.3389/fonc.2022.873682. eCollection 2022. (Editorial) (Impact Factor: 6.244)
  • Chakrabhavi Dhananjaya Mohan , Chulwon Kim , Kodappully Sivaraman Siveen , Kanjoormana Aryan Manu , Shobith Rangappa , Arunachalam Chinnathambi , Sulaiman Ali Alharbi , Kanchugarakoppal S Rangappa , Alan Prem Kumar , Kwang Seok Ahn . Crocetin imparts antiproliferative activity via inhibiting STAT3 signaling in hepatocellular carcinoma. IUBMB Life 2021 Sep 12. doi: 10.1002/iub.2555. Online ahead of print. (Impact Factor: 3.224)
  • Chai, T.F#., Manu, K.A#., Casey, P.J. et al. (#First authors with equal contribution) Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal. Oncogene 39, pages5373–5389(2020) (2020). https://doi.org/10.1038/s41388-020-1364-7 (Impact Factor: 9.687)
  • Manu KA, Cao PHA, Chai TF, Casey PJ, Wang M. p21cip1/waf1 Coordinate Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress. Cancers (Basel). 2019 Aug 3;11(8). pii: E1112. doi: 10.3390/cancers11081112. Review. (Impact Factor: 6.639)
  • Shanmugam MK, Ahn KS, Lee JH, Kannaiyan R, Mustafa N, Manu KA, Siveen KS, Sethi G, Chng WJ, Kumar AP. Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma. Front Pharmacol. 2018 May 3;9:365. doi: 10.3389/fphar.2018.00365. eCollection 2018. (Impact Factor: 4.4)
  • Manu KA, Chai TF, Teh JT, Zhu WL, Casey PJ, Wang M. Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. Molecular Cancer Therapeutics . 2017 May;16(5):914-923. doi: 10.1158/1535-7163.MCT-16-0703. Epub 2017 Feb 6. PubMed PMID: 28167504. (Impact Factor:6.261 )
  • Manu KA, Shanmugam MK, Ramachandran L, Li F, Siveen KS, Chinnathambi A, Zayed ME, Alharbi SA, Arfuso F, Kumar AP, Ahn KS, Sethi G.Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κB signalling cascade in gastric cancer. Cancer Lett. 2015 Jul 10;363(1):28-36. doi: 10.1016/j.canlet.2015.03.033. Epub 2015 Mar 28. (Impact Factor: 7.36)
  • Poyil Pratheeshkumar, Young-Ok Son, Preethi Korangath, Kanjoormana Aryan Manu, and Kodappully Sivaraman Siveen. Phytochemicals in Cancer Prevention and Therapy. Volume 2015, Article ID 324021, 2 pages (Impact Factor: NA)
  • Kanjoormana A. Manu, Muthu K. Shanmugam, Feng Li1, Luxi Chen, Kodappully Sivaraman Siveen, Kwang Seok Ahn, Alan Prem Kumar Gautam Sethi.. Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B regulated gene products, Journal of Molecular Medicine (Berl). 2014 Mar;92(3):267-76. (Impact Factor: 4.75)
  • Manu KA, Shanmugam MK, Ong TH, Subramaniam A, Siveen KS, Perumal E, Samy RP, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G. Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma. PLoS One. 2013;8(3):e57015. doi: 10.1371/journal.pone.0057015. Epub 2013 Mar 5. (Impact Factor:2.7)
  • Kanjoormana Aryan Manu, Muthu K. Shanmugam, Lalitha Ramachandran, Feng Li, Chee Wai Fong, Alan Prem Kumar, Patrick Tan, Gautam Sethi. First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. Clinical Cancer Research 2012 Apr 15;18(8):2220-9. Epub 2012 Feb 20. (Impact Factor: 13.8)
  • Kanjoormana Aryan Manu,  Hui  Sin Hay, Peramaiyan Rajendran, Muthu K Shanmugam, Feng Li,  Radhamani Kannaiyan,  Shireen Vali,  Shweta Kapoor, Bhargavi  Ramesh,  Pradeep Bist,  Evelyn S C Koay,  Lina H.K Lim,  Kwang  Seok Ahn, Alan Prem Kumar, and Gautam Sethi * Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4. . Mol Cancer. 2011 Sep 1;10:107. (Impact Factor:41.444)
  • Radhamani Kannaiyan#, Kanjoormana Aryan Manu # (Equal First author), Luxi Chen , Feng Li1, Peramaiyan Rajendran, Arul Joe Win1, Alan Prem Kumar, Gautam Sethi, Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-Terminal Kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. Apoptosis 2011 Oct;16(10):1028-41. (Impact Factor: 4.543)
  • Muthu K Shanmugam#, Kanjoormana Aryan Manu # (Equal First author), Lalitha Ramachandran, Tina H.Ong2,Rohit Surana, Pradeep Bist4, Lina H.K Lim, Alan Prem Kumar, Kam M.Hui and Gautam Sethi Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model. International Journal of Cancer 2011 Oct 1;129(7):1552-63. doi: 10.1002/ijc.26120. Epub 2011 Jul 20 (Impact Factor: 5.145)
  • Subramaniam A, Loo SY, Rajendran P, Manu KA, Perumal E, Li F, Shanmugam MK, Siveen KS, Park JI, Ahn KS, Hui KM, Kumar AP, Sethi G.An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins. Apoptosis 18 (10), 1175-1187, 2013 (Impact Factor: 4.453)
  • Maralinganadoddi Panchegowda Sadashiva, Basappa, Sivananju Najundaswamy, Feng Li, Kanjoormana Aryan Manu et al, Anticancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives. BMC Chemical Biology 2012, 12:5. (Impact Factor: NA)
  • Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT, Ashktorab H, Tan P, Ahn KS, Yap CW, Kumar AP, Sethi G. Isorhamnetin inhibits proliferation, invasion, and induces apoptosis through the modulation of peroxisome proliferator-activated receptor-gamma activation pathway in gastric cancer. Journal of Biological Chemistry 287 (45), 38028-38040 2012 (Impact Factor: 4.106)
  • Kuttan G, Pratheeshkumar P, Manu K.A,. Inhibition of tumor progression by naturally occurring terpenoids. Pharmaceutical Biology Pharm Biol. 2011 Oct;49(10):995-1007.( Review ) (Impact Factor: 2.14))
  • Rajendran P, Li F, Aryan MK, Shanmugam MK, Loo SY, Kumar AP, Sethi G. γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an anti-proliferative, pro-apoptotic and chemosensitizing agent. British journal of pharmacology 2010 Dec. ;163(2):283-98 (Impact Factor: 7.73)
  • Kanjoormana Manu, Girija Kuttan. Antiangiogenic activity of Ursolic acid. Integrative cancer therapies 2010 Jun; 9(2) (Impact Factor: 2.379)
  • K.A Manu, Girija Kuttan. Punarnavine induces apoptosis in B16F-10 melanoma cells by inhibiting NF-kB Signaling. Asian Pacific Journal of Cancer Prevention. 2009;10(6):1031-7. (Impact Factor: NA )
  • K.A. Manu, Girija Kuttan. Immunomodulatory activities of Punarnavine, an alkaloid from Boerhaavia diffusa. Immunopharmacology and Immunotoxicology 2009;31(3):377-87. (Impact Factor: 2.352)
  • K.A. Manu, Girija Kuttan. Anti-metastatic potential of Punarnavine, an alkaloid from Boerhaavia diffusa.Linn.  Immunobiology (2009) 214(4):245-55. (Impact Factor: 2.788)
  • K.A. Manu, Girija Kuttan. Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-κB mediated activation of bcl-2 in B16F-10melanoma cells. International Immunopharmacology (2008) 8, 974–981. (Impact Factor: 3.943)
  • K.A. Manu, Girija Kuttan. Boerhaavia diffusa stimulates cell-mediated immune response by upregulating IL-2 and downregulating the pro-inflammatory cytokines and GM-CSF in b16f-10 metastatic melanoma bearing mice Journal of experimental therapeutics and oncology, (2008), 7; 17-29. (Impact Factor: NA)
  • K. A. Manu and Girija Kuttan, 'Effect of Punarnavine, an Alkaloid from Boerhaavia diffusa, on Cell-Mediated Immune Responses and TIMP-1 in B16F-10 Metastatic Melanoma-Bearing Mice', Immunopharmacology and Immunotoxicology, (2007) 29:3, 569 – 586. (Impact Factor: 2.352) 
  • K.A. Manu, P.V. Leyon and Girija Kuttan Studies on the Protective Effects of Boerhaavia diffusa L. Against Gamma Radiation Induced Damage in Mice, Integr Cancer Ther 2007; 6; 381 (Impact Factor: 2.379)

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