Dr. Babu T. D.

Associate Professor BIOCHEMISTRY

• RESEARCH INTERESTS

  • Cancer biology, Drug discovery, Breast Cancer Signaling, Estrogen receptors, phyto estrogens, ER stress, Natural compounds.

• POSITIONS HELD

  • Asst. Professor, Department of Biochemistry, Amala Cancer Research Centre, Amala Nagar P O, Thrissur, Kerala ​
  • Research Associate, Non-Wood Forest Products Discipline, Kerala Forest Research Institute, Thrissur, Kerala. ( 2004 - 2008 )
  • Research Associate, Center for Plant Biotechnology and Molecular Biology (CPBMB), College of Horticulture, Kerala Agricultural University. P. O., Vellanikkara, Thrissur, Kerala. ( 1997 - 2003 )

• PROFESSIONAL MEMBERSHIPS

  • Associate Member – American Association for Cancer Research (AACR). No 159122, 2009
  • AVON Foundation – American Association for Cancer Research (AACR) International Scholarship Award for the paper entitled ‘Cytotoxic effects of Crystal proteins from Bacillus thuringiensis against breast cancer cells’. American Association for Cancer Research (AACR) - San Antonio Breast Cancer symposium 2008, Texas.
  • H.S. Mehta Memorial National Award for best research paper entitled ‘Detection of genetic diversity in Piper species using RAPD and AFLP markers’- National Seminar on New Perspective in Spices, Medicinal and Aromatic Plants at ICAR Complex, Goa on November, 2003

• PROJECTS

  • Analysis on estrogen receptor-β (ERβ) modulation by phytoestrogens of Saracaasoca (Asoka): Preventive and therapeutic strategy for triple negative breast cancer
    Funding Agency: KSCSTE ( 2022 - Ongoing )

• PUBLICATIONS

  • Aneesa V.M., Safna Hussan K.P., Lekshmi S., Babu T.D., Muraleedharan K. (2024) Analysis of non-linear optical properties of phytochemical photosensitizers in cancer photodynamic therapy by quantum computational. Results in Chemistry 8:101580
  • Safna H K P, Davis A, Lekshmi S, Thayyil M S, Raghavamenon A C, Babu T D (2024). Evaluation of the binding efficacy of flavonol derivatives on estrogen receptors (ER) with respect to ring B hydroxylation. Results in Chemistry, 7 2024/01/01/ 2024: 101544.
  • Hussan K P S, Layana J, Lekshmi S, Thayyil M S, Babu T D (2024). Exploring the anticancer potential of double-active pharmaceutical ingredient, metforminium ibuprofenate: Integrating in vivo and in silico investigations. Journal of Molecular Liquids 404, 124908.
  • Jayalakshmi J, Thomas T R, Sreelakshmi N S, Sunilkumar N S, Rajani C V, Lucy K M, Maya S, Varghese A, Aravindhakshan T V, Ashok N, Babu T D, Darvin P, and Chandrasekhar L (2024). Gross anatomy of vascular supply and drainage of mammary fat pads Pramod Darvin in mice models. Anatomia, Histologia, Embryologia, 53, e13045.
  • Safna H K P, Pareeth C M, Muraleedharan K, Shahin T M and Babu, T D (2022). Synthesis, spectroscopic, chemical reactivity, molecular docking, DFT calculations and in-vitro anticancer activity studies of a novel ionic liquid; Metforminium ibuprofenate. Journal of Molecular Liquids 364, 120046. doi.org/10.1016/j.molliq.2022.120046
  • Safna H K P, Babu T D, Pareeth C M, Greena J, Deepu M, Shahin T M (2022). Antioxidant activity of erlotinib and gefitinib: theoretical and experimental insights. Free Radicle Research 56 (2), 196-208. doi: 10.1080/10715762.2022.2065990.
  • Safna H K P, Abdul R K A, Medammal Z. Thayyil, M. S. Babu T D (2022). Theoretical insights into the radical scavenging activity of glipizide: DFT and molecular docking studies. Free Radicle Research 56(1): 53-62. doi: 10.1080/10715762.2022.2034803.
  • Sreepriya P K, Vijayan F P, Vijayan, F P, Pareeth C M, Padikkala J and Babu T D (2022). Cardioprotective effect of Justicia gendarussa on doxorubicin induced toxicity in mice. Journal of Basic Clinical and Physiological Pharmacology 24 (10), 2022-0085. doi: 10.1515/jbcpp-2022-0085.
  • Meera N, Divya M K, Silpa P, Pareeth C M, Raghavamenon A C and Babu T D (2021). Amelioration of sodium fluoride induced oxidative stress by Cynometra travancorica Bedd in mice. Journal of Complementary and Integrative Medicine 19(10), 2021-0120. doi: 10.1515/jcim-2021-0120.
  • Silpa P, Meera N, Shaji E M, Indu M S, Smitha K R, Kuzhivelil B T, Babu T D (2021). Neera, a non-fermented traditional drink from coconut spadix restores the redox status in sodium fluoride intoxicated mice. Journal of Complementary and Integrative Medicine 18(3):499-505. doi: 10.1515/jcim-2020-0074. PMID: 33544527.
  • Bini M, Rajesh B, Babu TD (2021). Chronic exposure of industrial grade calcium carbide and ethylene glycol exert genotoxic effect in Wistar albino rats. Journal of Basic Clinical and Physiological Pharmacology (ahead of print). doi: 10.1515/jbcpp-2020-0360.
  • Bini M, Rajesh B, Babu T D (2021). Chronic exposure of industrial grade calcium carbide and ethylene glycol alter histological architecture of systemic organs by disrupting redox balance in rat. Journal of Basic Clinical and Physiological Pharmacology 33(3): 265-271. doi: 10.1515/jbcpp-2020-0087.
  • Silpa P, Meera N, Shaji EM, Indu MS, Kuzhivelil BT, Babu TD (2020). Ameliorative effect of Neera, nonfermented coconut inflorescence sap, on cisplatin-induced renal toxicity by abating oxidative stress. Journal of Basic Clinical and Physiological Pharmacology 32(1) doi: 10.1515/jbcpp-2020-0028.
  • Bini M, Rajesh B, Babu T D (2019). Acute and subacute toxicity evaluation of calcium carbide and ethylene glycol in Wistar albino rats. Journal of Basic Clinical and Physiological Pharmacology 2019 31(1). doi: 10.1515/jbcpp-2019-0126. PMID: 31782949.
  • Chubicka T, Girija D, Deepa K, Salini S, Meera N, Raghavamenon A C, Divya M K and Babu T D (2018). A parasporin from Bacillus thuringiensis native to Peninsular India induces apoptosis in cancer cells through intrinsic pathway. Journal of Bioscience 43, 407-416.
  • Shahid AP, Sasidharan N, Salini S, Padikkala J, Meera N, Raghavamenon A C and Babu T D (2017). Kingiodendron pinnatum, a pharmacologically effective alternative for Saraca asoca in an Ayurvedic preparation, Asokarishta. Journal of Traditional and Complementary Medicine 8(1), 244-250.
  • Divya M K, Meera N, Raghavamenon AC and Babu T D (2017). Anti-inflammatory and gastro-protective effects of Apodytes dimidiata. South African Journal of Botany 108, 223-228.
  • Narayanankutty A, Jeksy M J, Indu M S Smitha K R, Shaji E M, Sooriya P I, Babu T D, Balu T K and Raghavamenon A C (2016). Deep fried edible oils disturb hepatic redox equilibrium and heighten lipotoxicity and hepatosteatosis in rats. Human and Experimental Toxicology 36(9), 919-930.
  • Narayanankutty A, Muneera V, Jeksy J M, Smitha K R, Indu M S, Babu T D and Raghavamenon A C (2016). Omega 3 fatty acids: Do they raise health concern? JSM Biochemistry and Molecular biology 3(1), 1016.
  • Roy N, Davis S, Narayanankutty A, Nazeem P, Babu T D, Abida P, Valsala P, Raghavamenon A C (2016). Garlic phytocompounds possess anticancer activity by specifically targeting breast cancer biomarkers - An in silico study. Asian Pacific Journal of Cancer Prevention 17(6), 2883-8.
  • Divya M K, Lincy L, Raghavamenon A C and Babu T D (2016). Ameliorative effect of Apodytes dimidiata on cisplatin-induced nephrotoxicity in Wistar rats. Pharmaceutical Biology 54(10), 2149-57.
  • Divya M K, Salini S, Meera N, Lincy L, Seema M, Raghavamenon A C and Babu T D (2016). Attenuation of DMBA/croton oil induced mouse skin papilloma by Apodytes dimidiata mediated by its antioxidant and antimutagenic potential. Pharmaceutical Biology 54(9), 1564-74.
  • Salini S, Divya M K, Chubicka T, Meera N, Fulzele D P, Ragavamenon A C and Babu T D (2016). Protective effect of Scutellaria species on AAPH-induced oxidative damage in human erythrocyte. Journal of Basic and Clinical Physiology and Pharmacology 27 (4) 403-9.
  • Divya M K, Salini S, Chubicka T, Raghavamenon A C and Babu T D (2015). Evaluation of cytotoxic and antitumour properties of Apodytes dimidiata and characterisation of the bioactive component. Planta Medica 81 (18), 1705-11.
  • Shahid A P, Salini S, Sasidharan N, Padikkala J, Raghavamenon A C and Babu T D (2015). Effect of Saraca asoca (Asoka) on estradiol induced keratinizing metaplasia in rat uterus. Journal of Basic and Clinical Physiology and Pharmacology 26 (5), 509-515.
  • Chubicka T, Girija D, Salini S, Achuthan CR and Babu T D (2015). Tumour inhibitory effect of a crystal protein from Bacillus thuringiensis isolate of Peninsular India. International Journal of Pharmaceutical Research 7 (2), 53-57.
  • Gopinath G, Sujesh M and Babu T D (2015). Evaluation of cytotoxic and anti-tumor activity of Phyllanthus acidus (L.) Skeels Leaf extracts. International Journal of Novel Research in Life Sciences 2(2), 24-31.
  • Divya M K, Dharmapal S, Achuthan C R and Babu T D (2014). Cytotoxic and antitumor effects of Tribulu sterrestris L fruit methanolic extract. Journal of Pharmacognosy and Phytochemistry 3 (2), 1-4.
  • Jeksy M J, Jayram P, Babu T D and Raghavamenon C R (2014). Anti-oxidant and anti-inflammatory properties of a non-toxic herbal formulation – GSTC. International Journal of PharmTech Research 6, 924-932.
  • Salini S, Chubicka T, Rghavamenon A C and Babu T D (2014). Evaluation of antioxidant activities of Radermachera xylocarpa K Schum. International Journal of PharmTech Research 6 (2), 704-709.
  • Smitha K R, Babu T D and Achuthan C R (2014). Phytochemical screening and in vitro cytotoxicity analysis of Uvaria naram (Dunal) wall. Asian Journal of Phytomedicine and Clinical Research 2 (2), 40- 47.

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